What is halobetasol propionate cream 05 used for

Fluorometholone ( INN , BAN , JAN ) (brand names Efflumidex , Flucon , FML Forte , FML , others), also known as 6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione , is a synthetic glucocorticoid which is used in the treatment of inflammatory eye diseases . [1] [2] [3] The C17α acetate ester , fluorometholone acetate (brand name Flarex), is also a glucocorticoid and is used for similar indications. [1] [2] [3] Specifically, it is indicated for use in the treatment of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye. [ citation needed ]

Like other topical corticosteroids, halobetasol propionate has anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of the anti- inflammatory activity of the topical corticosteroids, in general, is unclear However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins , collectively called lipocorins It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid Arachidonic acid is released from membrane phospholipids by phospholipase A 2 .

The normal inflammatory response to local infections can be masked by halobetasol. Application of topical corticosteroids to areas of infection, including tuberculosis of the skin, dermatologic fungal infection, and cutaneous or systemic viral infection (., measles or varicella), should be initiated or continued only if the appropriate antiinfective treatment is instituted. Herpes infection may be transmitted to other sites, including the eye. If the infection does not respond to the antimicrobial therapy, the concurrent use of the topical corticosteroid should be discontinued until the infection is controlled. Topical corticosteroids may delay the healing of non-infected wounds, such as venous stasis ulcers.

It was withdrawn from human use in the United States market in April 1994. [3] [4] The drug was previously available in the United Kingdom for use in humans under the brand name Modrenal for the treatment of Cushing's disease and for breast cancer. [5] [6] [7] It was approved in the United States in 2008 for the treatment of Cushing's disease (hyperadrenocorticism) in dogs under the brand name Vetoryl . [8] It was available by prescription in the UK under the Vetoryl brand name for some time before it was approved in the US. [9] The drug is also used to treat the skin disorder Alopecia X in dogs. [3] [10] [11] It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs. This prescription drug works by stopping the production of cortisol in the adrenal glands. [12] [13] In studies of the drug, the most common side effects were vomiting, lack of energy, diarrhea, and weight loss. Trilostane should not be given to a dog that:

What is halobetasol propionate cream 05 used for

what is halobetasol propionate cream 05 used for

It was withdrawn from human use in the United States market in April 1994. [3] [4] The drug was previously available in the United Kingdom for use in humans under the brand name Modrenal for the treatment of Cushing's disease and for breast cancer. [5] [6] [7] It was approved in the United States in 2008 for the treatment of Cushing's disease (hyperadrenocorticism) in dogs under the brand name Vetoryl . [8] It was available by prescription in the UK under the Vetoryl brand name for some time before it was approved in the US. [9] The drug is also used to treat the skin disorder Alopecia X in dogs. [3] [10] [11] It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs. This prescription drug works by stopping the production of cortisol in the adrenal glands. [12] [13] In studies of the drug, the most common side effects were vomiting, lack of energy, diarrhea, and weight loss. Trilostane should not be given to a dog that:

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