Alfatradiol binds to the ERα and ERβ with 58% and 11% of the relative binding affinity of 17β-estradiol.  However, it has 100-fold lower estrogenic activity relative to estradiol,  which may in part be due to differences in the intrinsic activity of the two compounds. [ citation needed ] On the other hand, alfatradiol has been found to bind to and activate the brain -expressed ER-X with a greater potency than estradiol, indicating that it may be the predominant endogenous ligand for the receptor. 
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