Tyramine pressor doses were also studied in 11 subjects after extended treatment with Emsam 12 mg per 24 hours. At 30, 60, and 90 days, the mean pressor doses (TYR30) of tyramine administered without food were 95 mg, 72 mg, and 88 mg, respectively. The lowest pressor dose without food was 25 mg in three subjects at day 30 while on Emsam 12 mg per 24 hours. Eight subjects from this study, with a mean tyramine pressor dose of 64 mg at 90 days, were subsequently administered tyramine with food, resulting in a mean pressor dose of 172 mg ( times the mean pressor dose observed without food, p less than ).
The treatment of burning mouth syndrome is usually directed at its symptoms and is the same as the medical management of other neuropathic pain conditions ( Table 2 ) . Studies generally support the use of low dosages of clonazepam (Klonopin), 26 chlordiazepoxide (Librium) 13 and tricyclic antidepressants (., amitriptyline [Elavil]). 27 Evidence also supports the utility of a low dosage of gabapentin (Neurontin). 28 Studies have not shown any benefit from treatment with selective serotonin reuptake inhibitors or other serotoninergic antidepressants (. trazodone [Desyrel]. 29 .)