Ingestion of glutamic acid (MSG) is known to produce a variety of adverse reactions in some people. These reactions, although seemingly dissimilar, are no more diverse than reactions found as side effects of certain neurological drugs. We do not know why some people experience reactions and others do not. We do not know whether MSG “causes” the condition underlying the reaction, or whether the underlying condition is simply aggravated by the ingestion of MSG. We only know that the reactions listed below are sometimes caused or exacerbated by MSG.
Chronic ingestion of bicarbonate may rarely cause intravascular volume expansion with resultant hyporeninemia and hypoaldosteronemia. In this rare circumstance, the serum potassium may be elevated.
Rare cases of sodium bicarbonate abuse have been associated with features of Munchausen syndrome. These patients often present with an otherwise unexplained hypokalemic hypochloremic metabolic alkalosis.
Hypernatremia may cause water retention, weight gain, and edema, which may be important in some patients with congestive heart failure, renal insufficiency, or severe liver disease. [ Ref ]