Distribution : Following intravenous administration of 1 mg of fluticasone propionate in healthy volunteers, the initial disposition phase for fluticasone propionate was rapid and consistent with its high lipid solubility and tissue binding. The apparent volume of distribution averaged L/kg (range, - L/kg). The percentage of fluticasone propionate bound to human plasma proteins averaged 91%. Fluticasone propionate is weakly and reversibly bound to erythrocytes. Fluticasone propionate is not significantly bound to human transcortin.
In propionic acidemia , a rare inherited genetic disorder, propionate acts as a metabolic toxin in liver cells by accumulating in mitochondria as propionyl-CoA and its derivative, methylcitrate, two tricarboxylic acid cycle inhibitors. Propanoate is metabolized oxidatively by glia , which suggests astrocytic vulnerability in propionic acidemia when intramitochondrial propionyl-CoA may accumulate. Propionic acidemia may alter both neuronal and glial gene expression by affecting histone acetylation.   When propionic acid is infused directly into rodents' brains, it produces reversible behavior (., hyperactivity , dystonia , social impairment, perseveration ) and brain changes (., innate neuroinflammation, glutathione depletion) that may be used as a means to model autism in rats. 
Eligible patients with a valid prescription for ADVAIR DISKUS (fluticasone propionate and salmeterol inhalation powder) or ADVAIR HFA (fluticasone propionate and salmeterol) Inhalation Aerosol who present this savings card at participating pharmacies will pay the first $10, and receive up to $50 off each 30-day prescription or refill of ADVAIR DISKUS or ADVAIR HFA applied to your out-of-pocket cost. This offer is good for up to 12 uses, and each 30-day supply counts as 1 use. Patient is responsible for applicable taxes, and remaining out of pocket cost, if any. This offer is limited to one per person and is nontransferable and cannot be combined with any other coupon, free trial or similar offer. No substitutions are permitted. Patients, pharmacists, and prescribers cannot seek reimbursement from health insurance or any third party for any part of the amount received by the patient through this offer. Offer must be presented along with a valid prescription for ADVAIR DISKUS or ADVAIR HFA at the time of purchase. Your acceptance of this offer must be consistent with the terms of any drug benefit plan provided to you by your health insurer. You agree to report your use of this coupon to your health insurer if required.